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She turns toward Preston, and, as if he senses the tension, the cringe on his face pivots into an awkward smile. He starts to laugh, and she does, too. CBD — or cannabidiol, as it’s known scientifically — is one of dozens of compounds in marijuana called cannabinoids. The compounds work by plugging into receptors on nerve cells, although much of their activity is still unclear. Tetrahydrocannabinol, or THC, is the most famous cannabinoid found in marijuana. But, unlike THC, CBD does not get users stoned. So, the entire day after that first dose, Ana watched Preston like a poker player looking for a tell. While doctors at Children’s don’t exactly want their patients on CBD, they are eager to find out what it’s doing. Knupp told Ana that doctors at the hospital now recommend all patients have both an EEG and a bloodwork exam prior to starting CBD. They would like to run follow-up tests every three or four months. Related: Epilepsy drug development is a sparse field But, when parents such as Ana Watson arrive with little more than a desperately sick child and a hope to make it better, they walk into uncharted territory. They become part of a medical experiment that plays out in living rooms, not doctors’ offices. Part 3 An early and oft-reported survey of children on Charlotte’s Web found that 80 percent who tried it eliminated at least three of every four of their seizures. Now, even one of the specialists involved in that study questions whether it was overly optimistic. Subsequent studies have suggested the response rate might be closer to 30 percent or, perhaps, even lower. Oklahoma The state health department, which manages the patient registry that all children using medical marijuana must join, offers almost no guidance. Ana gives Preston his CBD oil At the North Carolina Children’s Hospital in Chapel Hill in May, Dr. Robert Greenwood hustled into the meeting room wearing a tie covered with Dr. Seuss characters. Smaller numbers of children in California and other states have also begun to use marijuana to treat seizures. But what makes Colorado the epicenter is the state’s large medical marijuana system, which allows for kids to be registered patients; the growing community of families with sick children; and the feedback loop of publicity that surrounds the treatment. Every happy story about a family seeing success with cannabis in Colorado pushes another family to move here. May 8 The dregs of his afternoon seizure medications are still on his lips as Preston rests on his porch after a long day of school interrupted by numerous myoclonic seizures. Read More A roller coaster “We are proud to be industrial hemp industry pioneers in the state of TX. Through innovative thinking we will continue to formulate, research, and develop new products that revolutionize the way the world looks at hemp.” CEO No child in Colorado currently takes pure CBD. Instead, think of a marijuana plant like a chunk of gold ore. Only a tiny part of it is valuable; the rest needs to be refined away. To do this, CBD producers grow marijuana plants that are high in CBD and then use a solvent to dissolve the cannabinoids off the harvested plant material. The resulting slurry has the same cannabinoid makeup of the plant it came from. Depending on the method, the solvent may be evaporated away and the rest is diluted into oil. Preston gently touches his friend Hailey McGuire
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